Uterine Malignant Mixed Mullerian Tumor: Review of Recent Literature
نویسندگان
چکیده
Uterine Malignant Mixed Mullerian Tumor (MMMT) is an uncommon neoplasm with aggressive clinical course. It shares similar etiology, clinical and pathologic features of high-grade endometrial carcinoma. As such, uterine MMMT has been recently regarded as high grade de-differentiated endometrial carcinoma. Histologically, uterine MMMT is composed of an admixture of malignant epithelial and mesenchymal components. Substantial immunohistochemical and molecular genetic evidence has suggested that these two components share the same cellular origin and the mesenchymal component might derive from the epithelial component via epithelial-mesenchymal transition. This article reviews the recent literature related to the pathogenesis, histopathology, diagnosis, and management of uterine MMMT. [N A J Med Sci. 2017;10(3):110-115. DOI: 10.7156/najms.2017.1003110]
منابع مشابه
Malignant Mixed Mullerian Tumor of the Uterus Associated with Tamoxifen Therapy in a Patient with a History of Breast Cancer
Tamoxifen is the drug of choice in the treatment of breast cancer. Recent reports show an increased incidence of endometrial carcinoma in patients taking tamoxifen. In this article, we report a case of malignant mixed mullerian tumor after tamoxifen use.
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